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Republic of Korea

Prediction of species composition ratios in pooled specimens of the Anopheles Hyrcanus group using quantitative sequencing

August 10, 2021 - 18:32 -- Open Access
Do Eun Lee, Heung-Chul Kim, Sung-Tae Chong, Terry A. Klein, Ju Hyeon Kim and Si Hyeock Lee
Malaria Journal 2021 20:338, 6 August 2021

Plasmodium vivax is transmitted by members of the Anopheles Hyrcanus Group that includes six species in the Republic of Korea: Anopheles sinensis sensu stricto (s.s.), Anopheles pullus, Anopheles kleini, Anopheles belenrae, Anopheles lesteri, and Anopheles sineroides. Individual Anopheles species within the Hyrcanus Group demonstrate differences in their geographical distributions, vector competence and insecticide resistance, making it crucial for accurate species identification. Conventional species identification conducted using individual genotyping (or barcoding) based on species-specific molecular markers requires extensive time commitment and financial resources.

Humoral and cellular immune response to Plasmodium vivax VIR recombinant and synthetic antigens in individuals naturally exposed to P. vivax in the Republic of Korea

June 30, 2021 - 12:30 -- Open Access
Sanghyun Lee, Young-Ki Choi and Youn-Kyoung Goo
Malaria Journal 2021 20:288, 28 June 2021

Plasmodium vivax proteins with variant interspersed repeats (VIR) are the key proteins used by the parasite to escape from the host immune system through the creation of antigenic variations. However, few studies have been done to elucidate their role as targets of immunity. Thus, this study evaluated the naturally-acquired immune response against VIR proteins in vivax malaria-infected individuals in the Republic of Korea (ROK).

Multiplex PCR assay for the identification of eight Anopheles species belonging to the Hyrcanus, Barbirostris and Lindesayi groups

June 30, 2021 - 12:28 -- Open Access
Woo Jun Bang, Heung Chul Kim, Jihun Ryu, Hyeon Seung Lee, So Youn Lee, Myung Soon Kim, Sung Tae Chong, Terry A. Klein and Kwang Shik Choi
Malaria Journal 2021 20:287, 28 June 2021

Genus Anopheles mosquitoes are the primary vectors of human malaria, which is a serious threat to public health worldwide. To reduce the spread of malaria and identify the malaria infection rates in mosquitoes, accurate species identification is needed. Malaria re-emerged in 1993 in the Republic of Korea (ROK), with numbers peaking in 2004 before decreasing to current levels. Eight Anopheles species (Anopheles sinensis, Anopheles pullus, Anopheles belenrae, Anopheles lesteri, Anopheles kleini, Anopheles sineroides, Anopheles koreicus, Anopheles lindesayi) are distributed throughout Korea. Members of the Anopheles Hyrcanus group currently cannot be identified morphologically. The other species of Anopheles can be identified morphologically, except when specimens are damaged in traps. The purpose of this study was to develop a rapid and accurate method for simultaneous molecular identification of the eight Anopheles species present in the ROK.

Wing size and parity as markers of cohort demography for potential Anopheles (Culicidae: Diptera) malaria vectors in the Republic of Korea

December 3, 2020 - 12:22 -- Open Access
Foley DH, Wilkerson RC, Kim HC, Klein TA, Kim MS, Li C, Levin DM, Rueda LM
J Vector Ecol. 2020 Dec;45(2):366-379

Wing lengths of parous (P) and nulliparous (NP) PCR-identified female Anopheles belenrae, An. kleini, An. pullus, and An. sinensis were determined from weekly trap collections at Camp Humphreys (CH), Ganghwa Island (GH), and Warrior Base (WB), Republic of Korea (ROK) during Jun-Oct, 2009. Wing length was greatest at the beginning and end of the study period. Wing length of NPs tended to be less than that of Ps before the period of maximum greening (Jul-Aug) but greater thereafter.

NOT Open Access | Current Status and a Perspective of Mosquito-Borne Diseases in the Republic of Korea

November 4, 2020 - 14:36 -- NOT Open Access
Im JH, Kim TS, Chung MH, Baek JH, Kwon HY, Lee JS
Vector Borne Zoonotic Dis. 2020 Nov 2

Mosquito-borne diseases in the Republic of Korea have a unique epidemiology due to the rapid improvement in hygiene and economic status, occurrence of four distinct seasons, and separation from North Korea owing to the political situation. Therefore, we aimed to analyze and review the epidemiology of mosquito-borne diseases in Korea.

Investigation of glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence in a Plasmodium vivax-endemic area in the Republic of Korea (ROK)

September 2, 2020 - 11:47 -- Open Access
Wonsig Lee, Sang-Eun Lee, Min Jun Lee and Kyung Tae Noh
Malaria Journal 2020 19:317, 1 September 2020

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most prevalent inborn disorder. This X-chromosome-linked recessive disease affects more than 400 million people globally, and is associated with haemolytic anaemia after medication with the anti-latent malaria drug, primaquine. To prevent malaria, the Republic of Korea (ROK) Army administers malaria chemoprophylaxis. Due to the previously low G6PD deficiency prevalence in the ROK, prior to primaquine administration, testing for G6PD deficiency was not mandatory. In this study, to evaluate the risk from malaria chemoprophylaxis in the ROK, G6PD deficiency prevalence was investigated.

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