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children under five years

Prevalence and associated factors of malaria in children under the age of five years in Wogera district, northwest Ethiopia: A cross-sectional study

October 16, 2021 - 13:00 -- Open Access
Tsegaye AT, Ayele A, Birhanu S
PLoS One. 2021 Oct 11;16(10):e0257944

Malaria is a major public health problem in sub-Saharan Africa, and children are especially vulnerable. In 2019, an estimated 409,000 people died of malaria, most (274,000) were young children and 94% of the cases and deaths were in Africa. Prior studies in Ethiopia focused on the adult population and high transmission areas. Hence, this study aimed to determine the prevalence and associated factors of malaria in children under five years in low transmission areas.

Evaluation of direct costs associated with the management of clinical stage of malaria in children under five years old in Gabon

August 4, 2021 - 16:15 -- Open Access
Gaëtan Moukoumbi Lipenguet, Edgard Brice Ngoungou, Euloge Ibinga, Jean Engohang-Ndong and Jérôme Wittwer
Malaria Journal 2021 20:334, 30 July 2021

Malaria is one of the leading causes of morbidity and mortality in African countries. It is one of the leading causes of hospital visits and hospitalization in pediatric wards for children under 5 years old. Interestingly however, the economic burden of this disease remains unknown in these endemic countries including Gabon. The purpose of this study is to assess the direct hospital cost for the management of malaria in children under 5 years old at the Libreville University Hospital Centre (CHUL, Centre Hospitalier Universitaire de Libreville) in Gabon.

Bayesian network models with decision tree analysis for management of childhood malaria in Malawi

May 19, 2021 - 13:54 -- Open Access
Taneja SB, Douglas GP, Cooper GF, Michaels MG, Druzdzel MJ, Visweswaran S
BMC Med Inform Decis Mak. 2021 May 17;21(1):158

Malaria is a major cause of death in children under five years old in low- and middle-income countries such as Malawi. Accurate diagnosis and management of malaria can help reduce the global burden of childhood morbidity and mortality. Trained healthcare workers in rural health centers manage malaria with limited supplies of malarial diagnostic tests and drugs for treatment. A clinical decision support system that integrates predictive models to provide an accurate prediction of malaria based on clinical features could aid healthcare workers in the judicious use of testing and treatment. We developed Bayesian network (BN) models to predict the probability of malaria from clinical features and an illustrative decision tree to model the decision to use or not use a malaria rapid diagnostic test (mRDT).

Haematological profile of children with malaria in Sorong, West Papua, Indonesia

March 10, 2021 - 13:58 -- Open Access
Syilvia Jiero and Ayodhia Pitaloka Pasaribu
Malaria Journal 2021 20:126, 4 March 2021

Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Haematological changes, such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the haematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria.

Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations

March 3, 2021 - 15:45 -- Open Access
Paulina Tindana, Freek de Haan, Chanaki Amaratunga, Mehul Dhorda, Rob W. van der Pluijm, Arjen M. Dondorp and Phaik Yeong Cheah
Malaria Journal 2021 20:119, 27 February 2021

Malaria remains a major cause of morbidity and mortality in Africa, particularly in children under five years of age. Availability of effective anti-malarial drug treatment is a cornerstone for malaria control and eventual malaria elimination. Artemisinin-based combination therapy (ACT) is worldwide the first-line treatment for uncomplicated falciparum malaria, but the ACT drugs are starting to fail in Southeast Asia because of drug resistance.

NOT Open Access | Multilevel modelling of the risk of malaria among children aged under five years in Nigeria

September 22, 2020 - 10:31 -- NOT Open Access
Oguoma VM, Anyasodor AE, Adeleye AO, Eneanya OA, Mbanefo EC
Trans R Soc Trop Med Hyg. 2020 Sep 18:traa096

Malaria is still a major cause of morbidity and mortality among children aged <5 y (U5s). This study assessed individual, household and community risk factors for malaria in Nigerian U5s.

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