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metabolise pyrethroids

New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids

October 7, 2020 - 14:32 -- Open Access
Author(s): 
Lees RS, Ismail HM, Logan RAE, Malone D, Davies R, Anthousi A, Adolfi A, Lycett GJ, Paine MJI
Reference: 
Sci Rep. 2020 Oct 1;10(1):16232

Fenazaquin, pyridaben, tolfenpyrad and fenpyroximate are Complex I inhibitors offering a new mode of action for insecticidal malaria vector control. However, extended exposure to pyrethroid based products such as long-lasting insecticidal nets (LLINs) has created mosquito populations that are largely pyrethroid-resistant, often with elevated levels of P450s that can metabolise and neutralise diverse substrates.

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