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Kelch13 mutations in Plasmodium falciparum and risk of spreading in Amazon basin countries

August 17, 2021 - 15:42 -- Open Access
Mathieu LC, Singh P, Monteiro WM, Magris M, Cox H, Lazrek Y, Melo GC, Marchesini P, Alexandre JSF, Alvarez AM, Demar M, Douine M, Ade MP, Lacerda MVG, Musset L
J Antimicrob Chemother. 2021 Aug 11:dkab264

The first potential focus for artemisinin resistance in South America was recently confirmed with the presence of the C580Y mutation in the Plasmodium falciparum kelch 13 gene (pfk13) in Guyana. This study aimed to strengthen pfk13 monitoring in the Amazon basin countries, to compile the available data and to evaluate the risk of spreading of mutations.

Assessment of compliance with malaria treatment monitoring and cure verification activities

December 23, 2020 - 10:30 -- Open Access
Nascimento TLD, Vasconcelos SP, Andrade RLP, Bertolozzi MR, Souza KMJ
Rev Esc Enferm USP. 2020 Dec 11;54:e03655

To assess compliance with treatment monitoring and cure verification activities by Malaria Control Program professionals.

Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies

October 31, 2020 - 09:35 -- Open Access
Rocha EM, Katak RM, Campos de Oliveira J, Araujo MDS, Carlos BC, Galizi R, Tripet F, Marinotti O, Souza-Neto JA
Trop Med Infect Dis. 2020 Oct 20;5(4):E161

In Brazil, malaria transmission is mostly confined to the Amazon, where substantial progress has been made towards disease control in the past decade. Vector control has been historically considered a fundamental part of the main malaria control programs implemented in Brazil. However, the conventional vector-control tools have been insufficient to control or eliminate local vector populations due to the complexity of the Amazonian rainforest environment and ecological features of malaria vector species in the Amazon, especially Anopheles darlingi.

An integrated dataset of malaria notifications in the Legal Amazon

June 6, 2020 - 15:04 -- Open Access
Baroni L, Pedroso M, Barcellos C, Salles R, Salles S, Paixão B, Chrispino A, Guedes G, Ogasawara E
BMC Res Notes. 2020 Jun 3; 13(1):274

Malaria is an infectious disease that annually presents around 200,000 cases in Brazil. The availability of data on malaria is crucial for enabling and supporting studies that can promote actions to prevent it. Therefore, the goal of this paper is to contribute to such studies by offering an integrated dataset containing data on reported and suspected cases of malaria in the Brazilian Legal Amazon comprising the period from the years 2009 to 2019.

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

May 13, 2020 - 14:50 -- Open Access
Mathieu LC, Cox H, Musset L, et al.
Elife. 2020 May 12;9. pii: e51015

Antimalarial drug resistance has historically arisen through convergent de novo mutations in Plasmodium falciparum parasite populations in Southeast Asia and South America. For the past decade in Southeast Asia, artemisinins, the core component of first-line antimalarial therapies, have experienced delayed parasite clearance associated with several pfk13 mutations, primarily C580Y.

Prospective assessment of malaria infection in a semi-isolated Amazonian indigenous Yanomami community: Transmission heterogeneity and predominance of submicroscopic infection

March 23, 2020 - 14:18 -- Open Access
Robortella DR, Calvet AA, Carvalho LH, et al.
PLoS ONE 15(3): e0230643

In the Amazon basin, indigenous forest-dwelling communities typically suffer from a high burden of infectious diseases, including malaria. Difficulties in accessing these isolated ethnic groups, such as the semi-nomadic Yanomami, make official malaria data largely underestimated. In the current study, we longitudinally surveyed microscopic and submicroscopic malaria infection in four Yanomami villages of the Marari community in the northern-most region of the Brazilian Amazon.

Not Open Access | Amazon deforestation drives malaria transmission, and malaria burden reduces forest clearing

November 5, 2019 - 12:45 -- NOT Open Access
Andrew J. MacDonald and Erin A. Mordecai
PNAS October 29, 2019 116 (44) 22212-22218

Deforestation and land use change are among the most pressing anthropogenic environmental impacts. In Brazil, a resurgence of malaria in recent decades paralleled rapid deforestation and settlement in the Amazon basin, yet evidence of a deforestation-driven increase in malaria remains equivocal.

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