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human-antibodies

NOT Open Access | Mathematical assessment of the impact of human-antibodies on sporogony during the within-mosquito dynamics of Plasmodium falciparum parasites

December 30, 2020 - 12:59 -- NOT Open Access
Author(s): 
Teboh-Ewungkem MI, Woldegerima WA, Ngwa GA
Reference: 
J Theor Biol. 2020 Dec 22:110562

We develop and analyze a deterministic ordinary differential equation mathematical model for the within-mosquito dynamics of the Plasmodium falciparum malaria parasite. Our model takes into account the action and effect of blood resident human-antibodies, ingested by the mosquito during a blood meal from humans, in inhibiting gamete fertilization. The model also captures subsequent developmental processes that lead to the different forms of the parasite within the mosquito. Continuous functions are used to model the switching transition from oocyst to sporozoites as well as human antibody density variations within the mosquito gut are proposed and used.

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