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randomized clinical trial

NOT Open Access | Efficacy and safety of malarial prophylaxis with mefloquine during pregnancy in Kisangani, Democratic Republic of Congo: a randomized clinical trial

January 6, 2021 - 12:37 -- NOT Open Access
Labama Otuli N, Marini Djang'eing'a R, Manga Okenge JP, et al.
Br J Clin Pharmacol. 2021 Jan 4

Kisangani is an area with intense malaria transmission and sulfadoxine‐pyrimethamine resistance. Alternative anti‐malaria prophylaxis medication and protocols are needed, particularly with pregnant individuals. In this study, we compare the tolerance and effectiveness of mefloquine regimen as a split dose with meal versus sulfadoxine‐pyrimethamine for the intermittent preventive treatment in pregnant individuals in Kisangani.

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