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inversion 2Rc

A PCR-RFLP method for genotyping of inversion 2Rc in Anopheles coluzzii

March 23, 2021 - 14:42 -- Open Access
Montanez-Gonzalez R, Vallera AC, Besansky NJ, et al.
Parasit Vectors. 2021 Mar 22;14(1):174

Genotyping of polymorphic chromosomal inversions in malaria vectors such as An. coluzzii Coetzee & Wilkerson is important, both because they cause cryptic population structure that can mislead vector analysis and control and because they influence epidemiologically relevant eco-phenotypes. The conventional cytogenetic method of genotyping is an impediment because it is labor intensive, requires specialized training, and can be applied only to one gender and developmental stage. Here, we circumvent these limitations by developing a simple and rapid molecular method of genotyping inversion 2Rc in An. coluzzii that is both economical and field-friendly. This inversion is strongly implicated in temporal and spatial adaptations to climatic and ecological variation, particularly aridity.

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