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Mechanisms and targets of Fcgamma-receptor mediated immunity to malaria sporozoites

March 23, 2021 - 14:49 -- Open Access
Feng G, Wines BD, Beeson JG, et al.
Nat Commun. 2021 Mar 19;12(1):1742

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of antibody-mediated immunity is crucial for developing vaccines with high efficacy. Here, we identify key roles in humoral immunity for Fcγ-receptor (FcγR) interactions and opsonic phagocytosis of sporozoites. We identify a major role for neutrophils in mediating phagocytic clearance of sporozoites in peripheral blood, whereas monocytes contribute a minor role.

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