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B cells

Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria

November 23, 2021 - 09:18 -- Open Access
S. Jake Gonzales, Sebastiaan Bol, Ashley E. Braddom, Richard Sullivan, Raphael A. Reyes, Isaac Ssewanyana, Erica Eggers, Bryan Greenhouse and Evelien M. Bunnik
Malaria Journal 2021 20:435, 10 November 2021

Chronic and frequently recurring infectious diseases, such as malaria, are associated with expanded populations of atypical memory B cells (MBCs). These cells are different from classical MBCs by the lack of surface markers CD21 and CD27 and increased expression of inhibitory receptors, such as FcRL5. While the phenotype and conditions leading to neogenesis of atypical MBCs in malaria-experienced individuals have been studied extensively, the origin of these cells remains equivocal. Functional similarities between FcRL5+ atypical MBCs and FcRL5+ classical MBCs have been reported, suggesting that these cells may be developmentally related.

Osteopontin and malaria: no direct effect on parasite growth, but correlation with P. falciparum-specific B cells and BAFF in a malaria endemic area

November 10, 2021 - 20:59 -- Open Access
Mortazavi SE, Lugaajju A, Kaddumukasa M, Tijani MK, Kironde F, Persson KEM
BMC Microbiol. 2021 Nov 6;21(1):307

The dysregulation of B cell activation is prevalent during naturally acquired immunity against malaria. Osteopontin (OPN), a protein produced by various cells including B cells, is a phosphorylated glycoprotein that participates in immune regulation and has been suggested to be involved in the immune response against malaria. Here we studied the longitudinal concentrations of OPN in infants and their mothers living in Uganda, and how OPN concentrations correlated with B cell subsets specific for P. falciparum and B cell activating factor (BAFF). We also investigated the direct effect of OPN on P. falciparum in vitro.

B Cell Receptor Repertoire Analysis in Malaria-Naive and Malaria-Experienced Individuals Reveals Unique Characteristics of Atypical Memory B Cells

September 23, 2021 - 11:36 -- Open Access
Braddom AE, Bol S, Gonzales SJ, Reyes RA, Musinguzi K, Nankya F, Ssewanyana I, Greenhouse B, Bunnik EM
mSphere. 2021 Sep 15:e0072621

Malaria, caused by parasites of the Plasmodium genus, is responsible for significant morbidity and mortality globally. Chronic Plasmodium falciparum exposure affects the B cell compartment, leading to the accumulation of atypical memory B cells (atMBCs). IgM-positive (IgM+) and IgG+ atMBCs have not been compared in-depth in the context of malaria, nor is it known if atMBCs in malaria-experienced individuals are different from phenotypically similar B cells in individuals with no known history of Plasmodium exposure.

NOT Open Access | Linking microbiota composition with antimalarial antibody response

August 17, 2021 - 14:34 -- NOT Open Access
Romoli O, Mancio-Silva L, Gendrin M
Trends Parasitol. 2021 Aug 11:S1471-4922(21)00172-0

Microbiota composition recently arose as a factor correlating with malaria infection. Mandal et al. showed, via cecal transplant and antibacterial treatment, that the mouse microbiota modulates parasitemia by affecting spleen germinal centers where B cells are matured. They further identified correlations between microbiota composition and malaria severity in Ugandan children.

Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response

October 15, 2020 - 08:50 -- Open Access
McNamara HA, Idris AH, Cockburn IA, et al.
Cell Host Microbe. 2020 Oct 7;28(4):572-585.e7

Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here, we show that antibody titers to a key target, the repeat region of the Plasmodium falciparum circumsporozoite protein (PfCSP), plateaued after two immunizations in a clinical trial of the radiation-attenuated sporozoite vaccine. To understand the mechanisms limiting vaccine responsiveness, we developed immunoglobulin (Ig)-knockin mice with elevated numbers of PfCSP-binding B cells.

NOT Open Access | B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection

February 17, 2020 - 12:05 -- NOT Open Access
Arroyo EN, Pepper M
J Exp Med. 2020 Feb 3;217(2). pii: e20190849

CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood-stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression.

Not Open Access | B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection

November 30, 2019 - 20:01 -- NOT Open Access
Arroyo EN, Pepper M.
J Exp Med. 2019 Nov 20. pii: jem.20190849.

CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood-stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression. We studied antigen-specific CD4+ Tfh cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response.

Corrigendum: Chronic Exposure to Malaria Is Associated with Inhibitory and Activation Markers on Atypical Memory B Cells and Marginal Zone-Like B Cells

November 7, 2019 - 22:03 -- Open Access
Ubillos I, Campo JJ, Requena P, Ome-Kaius M, Hanieh S, Rose H, Samol P, Barrios D, Jiménez A, Bardají A, Mueller I, Menéndez C, Rogerson S, Moncunill G, Dobaño C.
Front Immunol. 2019 Oct 17;10:2427 (eCollection 2019)

In the original article, we neglected to include the co-funder “FEDER funds/European Regional Development Fund (ERDF)” to “Instituto de Salud Carlos III (grant number PI14/01422)”.

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