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NOT Open Access | Ammonium transporter AcAmt mutagenesis uncovers reproductive and physiological defects without impacting olfactory responses to ammonia in the malaria vector mosquito Anopheles coluzzii

May 5, 2021 - 08:24 -- NOT Open Access
Ye Z, Liu F, Ferguson ST, Baker A, Pitts RJ, Zwiebel LJ
Insect Biochem Mol Biol. 2021 Apr 29:103578

Anopheline mosquitoes are the sole vectors of malaria and rely on olfactory cues for host seeking in which ammonia derived from human sweat plays an essential role. To investigate the function of the Anopheles coluzzii ammonium transporter (AcAmt) in the mosquito olfactory system, we generated an AcAmt null mutant line using CRISPR/Cas9.

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