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PfSR1

An SR protein is essential for activating DNA repair in malaria parasites

July 28, 2021 - 13:49 -- Open Access
Author(s): 
Goyal M, Singh BK, Simantov K, Kaufman Y, Eshar S, Ron D
Reference: 
J Cell Sci. 2021 Jul 22:jcs.258572

Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria, replicates within the erythrocytes of its host where it encounters numerous pressures that cause extensive DNA damage, which must be repaired efficiently to ensure parasite survival. Malaria parasites, which lost the NHEJ pathway for repairing DNA double strand breaks, have evolved unique mechanisms that enable them to robustly maintain genome integrity under such harsh conditions. However, the nature of these adaptations is unknown.

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