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endocytosis

The newly discovered role of endocytosis in artemisinin resistance

July 28, 2021 - 14:37 -- Open Access
Author(s): 
Behrens HM, Schmidt S, Spielmann T
Reference: 
Med Res Rev. 2021 Jul 26

Artemisinin and its derivatives (ART) are the cornerstone of malaria treatment as part of artemisinin combination therapy (ACT). However, reduced susceptibility to artemisinin as well as its partner drugs threatens the usefulness of ACTs. Single point mutations in the parasite protein Kelch13 (K13) are necessary and sufficient for the reduced sensitivity of malaria parasites to ART but several alternative mechanisms for this resistance have been proposed.

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