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MR

Cerebral malaria: insight into pathology from optical coherence tomography

August 11, 2021 - 14:53 -- Open Access
Author(s): 
Tu Z, Gormley J, Sheth V, Seydel KB, Taylor T, Beare N, Barrera V, Proudlock FA, Manda C, Harding S, Gottlob I
Reference: 
Sci Rep. 2021 Aug 3;11(1):15722

We aimed to investigate structural retinal changes in malarial retinopathy (MR) using hand-held optical coherence tomography (HH-OCT) to assess its diagnostic potential. Children with MR (n = 43) underwent ophthalmoscopy, fluorescein angiography and HH-OCT during admission, 1-month (n = 31) and 1-year (n = 8) post-discharge. Controls were comatose patients without malaria (n = 6) and age/sex-matched healthy children (n = 43). OCT changes and retinal layer thicknesses were compared. On HH-OCT, hyper-reflective areas (HRAs) were seen in the inner retina of 81% of MR patients, corresponding to ischaemic retinal whitening on fundus photography.

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