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sickle cell anemia

Decreased parasite burden and altered host response in children with sickle cell anemia and severe anemia with malaria

September 8, 2021 - 15:56 -- Open Access
Author(s): 
Henrici RC, Sautter CL, Bond C, Opoka RO, Namazzi R, Datta D, Ware RE, Conroy AL, John CC
Reference: 
Blood Adv. 2021 Sep 1:bloodadvances.2021004704

Plasmodium falciparum malaria causes morbidity and mortality in African children with sickle cell anemia (SCA), but comparisons of host responses to P. falciparum between children with SCA (HbSS) and HbAA are limited. We assessed parasite biomass and plasma markers of inflammation and endothelial activation in children with HbAA (n=208) or HbSS (n=22) who presented with severe anemia and P. falciparum parasitemia to Mulago Hospital in Kampala, Uganda. Genotyping was performed at study completion.

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