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single-genome sequencing

NOT Open Access | Single-genome sequencing reveals within-host evolution of human malaria parasites

September 8, 2021 - 17:05 -- NOT Open Access
Dia A, Jett C, Trevino SG, Chu CS, Sriprawat K, Anderson TJC, Nosten F, Cheeseman IH
Cell Host Microbe. 2021 Sep 1:S1931-3128(21)00385-1

Population genomics of bulk malaria infections is unable to examine intrahost evolution; therefore, most work has focused on the role of recombination in generating genetic variation. We used single-cell sequencing protocol for low-parasitaemia infections to generate 406 near-complete single Plasmodium vivax genomes from 11 patients sampled during sequential febrile episodes.

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