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peripheral parasitaemia

Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

October 2, 2021 - 13:10 -- Open Access
Author(s): 
Silva-Filho JL, Dos-Santos JC, Judice CC, Beraldi D, Venugopal K, De Lima D, Nakaya H, Paula EE, Costa Pinto Lopes S, Lacerda MV, Marti M, Costa FT
Reference: 
Elife. 2021 Sep 29;10:e71351

Plasmodium vivax is the major cause of human malaria in the Americas. How P. vivax infection can lead to poor clinical outcomes, despite low peripheral parasitaemia remains a matter of intense debate. Estimation of total P. vivax biomass based on circulating markers indicates existence of a predominant parasite population outside of circulation. In this study we investigate associations between both peripheral and total parasite biomass and host response in vivax malaria. We analysed parasite and host signatures in a cohort of uncomplicated vivax malaria patients from Manaus, Brazil, combining clinical and parasite parameters, multiplexed analysis of host responses and ex vivo assays. Patterns of clinical features, parasite burden and host signatures measured in plasma across the patient cohort were highly heterogenous.

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