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molecular mechanisms

Linking functional and molecular mechanisms of host resilience to malaria infection

October 16, 2021 - 20:03 -- Open Access
Kamiya T, Davis NM, Greischar MA, Schneider D, Mideo N
Elife. 2021 Oct 12;10:e65846

It remains challenging to understand why some hosts suffer severe illnesses, while others are unscathed by the same infection. We fitted a mathematical model to longitudinal measurements of parasite and red blood cell density in murine hosts from diverse genetic backgrounds to identify aspects of within-host interactions that explain variation in host resilience and survival during acute malaria infection.

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