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NOT Open Access | Effect of immune regulatory pathways after immunization with GMZ2 malaria vaccine candidate in healthy lifelong malaria-exposed adults

May 13, 2020 - 13:57 -- NOT Open Access
Nouatin O, Ateba Ngoa U, Adegnika AA, et al.
Vaccine. 2020 May 5. pii: S0264-410X(20)30540-5

Despite appreciable immunogenicity in malaria-naive populations, many candidate malaria vaccines are considerably less immunogenic in malaria-exposed populations. This could reflect induction of immune regulatory mechanisms involving Human Leukocyte Antigen G (HLA-G), regulatory T (Treg), and regulatory B (Breg) cells. Here, we addressed the question whether there is correlation between these immune regulatory pathways and both plasmablast frequencies and vaccine-specific IgG concentrations.

Is Malaria an Important Cause of Death among Adults

April 23, 2020 - 09:57 -- Open Access
Gelband H, Bogoch II, Rodriguez PS, Ngai M, Peer N, Watson LK, Jha P
Am J Trop Med Hyg. 2020 Apr 20

A long-held assumption has been that nearly all malaria deaths in high-transmission areas are of children younger than 5 years and pregnant women. Most global malaria mortality estimates incorporate this assumption in their calculations. In 2010, the Indian Million Death Study, which assigns cause of death by verbal autopsy (VA), challenged the reigning perception, producing a U-shaped mortality age curve, with rates rising after age 45 years in areas of India with substantial malaria transmission.

NOT Open Access | Management and treatment of uncomplicated imported malaria in adults. Update of the French malaria clinical guidelines

March 3, 2020 - 15:15 -- NOT Open Access
Epelboin L, Rapp C, Faucher JF, Méchaï F, Bottieau E, Matheron S, Malvy D, Caumes E
Med Mal Infect. 2020 Mar;50(2):194-212


  • The diagnosis of malaria should always be considered in travelers returning from an endemic area and presenting with fever or a history of fever, either isolated or combined with other general, digestive, and/or respiratory symptoms, even if appropriate chemoprophylaxis was used.
  • Outpatient management of uncomplicated Plasmodium falciparum malaria may be implemented if precise clinical and biological criteria are met and if medical follow-up is possible.

Concomitant bacteremia in adults with severe falciparum malaria

March 3, 2020 - 13:11 -- Open Access
Phu NH, Day NPJ, White NJ, et al.
Clin Infect Dis. 2020 Feb 28. pii: ciaa191

Approximately 6% of children hospitalised with severe falciparum malaria in Africa are also bacteremic. It is therefore recommended that all children with severe malaria should receive broad spectrum antibiotics in addition to parenteral artesunate. Empirical antibiotics are not recommended currently for adults with severe malaria.

Stage-specific Plasmodium falciparum immune responses in afebrile adults and children living in the Greater Accra Region of Ghana

February 14, 2020 - 16:32 -- Open Access
Festus K. Acquah, Aminata C. Lo, Kwadwo Akyea-Mensah, Hamza B. Abagna, Babacar Faye, Michael Theisen, Ben A. Gyan and Linda E. Amoah
Malaria Journal 2020 19:64, 10 February 2020

Asymptomatic carriage of Plasmodium falciparum is widespread in adults and children living in malaria-endemic countries. This study identified the prevalence of malaria parasites and the corresponding levels of naturally acquired anti-parasite antibody levels in afebrile adults living in two communities in the Greater Accra Region of Ghana.

Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

January 20, 2020 - 15:27 -- Open Access
Elijah Kakande, Bryan Greenhouse, Isabel Rodriguez-Barraquer, et al.
Malaria Journal 2020 19:21, 15 January 2020

Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear.

Associations Between Restrictive Fluid Management and Renal Function and Tissue Perfusion in Adults With Severe Falciparum Malaria: A Prospective Observational Study

January 7, 2020 - 14:09 -- Open Access
Ishioka H, Plewes K, Dondorp AM, et al.
The Journal of Infectious Diseases, Volume 221, Issue 2, 15 January 2020, Pages 285–292

Liberal fluid resuscitation has proved harmful in adults with severe malaria, but the level of restriction has not been defined.

Description of Plasmodium falciparum infections in central Gabon demonstrating high parasite densities among symptomatic adolescents and adults

November 26, 2019 - 14:40 -- Open Access
Rella Zoleko Manego, Erik Koehne, Andrea Kreidenweiss, Brice Nzigou Mombo, Bayode Romeo Adegbite, Lia Betty Dimessa Mbadinga, Malik Akinosho, Julian Matthewman, Ayola Akim Adegnika, Michael Ramharter and Ghyslain Mombo-Ngoma
Malaria Journal 2019 18:371, 21 November 2019

Malaria remains a public health issue, particularly in sub-Saharan Africa with special features of seriousness in young children and pregnant women. Adolescents and adults are reported to have acquired a semi-immune status and, therefore, present with low parasitaemia. Children are understood to present with a much higher parasitaemia and severe malaria. It is a concern that effective malaria control programmes targeting young children may lead to a delay in the acquisition of acquired immunity and, therefore, causing a shift in the epidemiology of malaria. Prevalence and parasitaemia were explored in adolescents and adults with Plasmodium falciparum infections compared to young children in the area of Lambaréné, Gabon as an indicator for semi-immunity.


Histone deacetylase inhibitors with high in vitro activities against Plasmodium falciparum isolates collected from Gabonese children and adults

November 26, 2019 - 13:39 -- Open Access
Koehne E, Kreidenweiss A, Zoleko Manego R, McCall M, Mombo-Ngoma G, Mackwitz MKW, Hansen FK, Held J.
Scientific Reports volume 9, Article number: 17336 (2019)

Histone deacetylase (HDAC) enzymes are targets for the development of antimalarial drugs with a different mode of action to established antimalarials. Broad-spectrum HDAC-inhibitors show high potency against Plasmodium falciparum, but displayed some toxicity towards human cells. Inhibitors of human HDAC6 are new drug candidates with supposed reduced toxicity to human cells and favorable activities against laboratory P. falciparum strains.



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