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Not Open Access | Inflammatory cytokine responses in children with asymptomatic malaria infection living in rural, semi-urban and urban areas in south-eastern Gabon

August 10, 2021 - 18:01 -- NOT Open Access
Mbani Mpega Ntigui CN, Oyegue-Liabagui SL, Kouna LC, Imboumy KR, Tsafack Tegomo NP, Okouga AP, Ontoua S, Lekana-Douki JB
Clin Exp Immunol. 2021 Aug 7

Cytokines are soluble mediators of the immune response and their evolution influences the disease outcome. Gaining knowledge on cytokines has become important since they can constitute biomarkers allowing the diagnosis of malaria and preventing severe forms of the disease. Here, we investigated ten cytokines and their circulating levels in asymptomatic Gabonese children with Plasmodium falciparum infection living in urban, semi-urban and rural areas.

NOT Open Access | Mixed Plasmodium Malariae Infections Were Underdetected in a Malaria Endemic Area in the Amazon Region, Brazil

August 10, 2021 - 17:38 -- NOT Open Access
Cunha MG, Santos CS, Raiol M, Costa SPT, Ventura AMR, Póvoa MM, Ribeiro-Dos-Santos Â
Am J Trop Med Hyg. 2021 Aug 9:tpmd210296

Plasmodium malariae infections are often asymptomatic and long-lasting. Mixed infections are often underdetected in areas where P. malariae, P. vivax, and P. falciparum are coendemic.

Clustering of subpatent infections in households with asymptomatic rapid diagnostic test-positive cases in Bioko Island, Equatorial Guinea independent of travel to regions of higher malaria endemicity: a cross-sectional study

July 14, 2021 - 11:13 -- Open Access
Dianna E. B. Hergott, Jennifer E. Balkus, Sean C. Murphy, et al.
Malaria Journal 2021 20:313, 12 July 2021

Prevalence of falciparum malaria on Bioko Island remains high despite sustained, intensive control. Progress may be hindered by high proportions of subpatent infections that are not detected by rapid diagnostic tests (RDT) but contribute to onward transmission, and by imported infections. Better understanding of the relationship between subpatent infections and RDT-detected infections, and whether this relationship is different from imported versus locally acquired infections, is imperative to better understand the sources of infection and mechanisms of transmission to tailor more effective interventions.

NOT Open Access | Asymptomatic malaria infection prevailing risks for human health and malaria elimination

July 6, 2021 - 14:54 -- NOT Open Access
Prusty D, Gupta N, Upadhyay A, Dar A, Naik B, Kumar N, Prajapati VK
Infect Genet Evol. 2021 Jun 30:104987

There has been a consistent rise in malaria cases in the last few years. The existing malaria control measures are challenged by insecticide resistance in the mosquito vector, drug résistance in parasite populations, and asymptomatic malaria (ASM) in healthy individuals. The absence of apparent malaria symptoms and the presence of low parasitemia makes ASM a hidden reservoir for malaria transmission and an impediment in malaria elimination efforts.

NOT Open Access | Sizing the reservoirs of malaria transmission: the contribution of school-aged children

June 23, 2021 - 13:55 -- NOT Open Access
Mayor A, Bassat Q
Lancet Infect Dis. 2021 Jun 16:S1473-3099(21)00130-4

Peaceful coexistence with the infected host, commonly not causing clinical symptoms, is a frequent but poorly understood effect for many human pathogens, including Plasmodium falciparum.

Reactive, self-administered malaria treatment against asymptomatic malaria infection: results of a cluster randomized controlled trial in The Gambia

June 9, 2021 - 07:47 -- Open Access
Joseph Okebe, Edgard Dabira, Umberto D’Alessandro, et al.
Malaria Journal 2021 20:253, 7 June 2021

Selectively targeting and treating malaria-infected individuals may further decrease parasite carriage in low-burden settings. Using a trans-disciplinary approach, a reactive treatment strategy to reduce Plasmodium falciparum prevalence in participating communities was co-developed and tested.

NOT Open Access | Asymptomatic falciparum and Non-falciparum Malarial Parasitemia in Adult Volunteers with and without HIV-1 Coinfection in a Cohort Study in Western Kenya

June 9, 2021 - 07:29 -- NOT Open Access
Kifude C, Stiffler D, Stewart VA, et al.
Am J Trop Med Hyg. 2021 Jun 7:tpmd210012

Asymptomatic malarial parasitemia represents the largest reservoir of infection and transmission, and the impact of coinfection with HIV-1 on this reservoir remains incompletely described. Accordingly, we sought to determine the prevalence of asymptomatic malarial parasitemia in Kombewa, Western Kenya, a region that is endemic for both malaria and HIV-1. A total of 1,762 dried blood spots were collected from asymptomatic adults in a cross-sectional study.

High incidence of asymptomatic cases during an outbreak of Plasmodium malariae in a remote village of Malaysian Borneo

June 9, 2021 - 07:14 -- Open Access
Binti Naserrudin NA, Binti Abdul Aziz EI, Aljet E, Mangunji G, Tojo B, Jeffree MS, Culleton R, Ahmed K
PLoS Negl Trop Dis. 2021 Jun 3;15(6):e0009450

An outbreak of Plasmodium malariae occurred in Sonsogon Paliu village in the remote area of Ulu Bengkoka sub-district of Kota Marudu, Northern Sabah, Malaysian Borneo from July through August 2019. This was the first outbreak of malaria in this village since 2014. On 11th July 2019 the Kota Kinabalu Public Health Laboratory notified the Kota Marudu District Health Office of a Polymerase Chain Reaction (PCR) positive case of P. malariae. This index case was a male from Sulawesi, Indonesia working for a logging company operating in Sonsogon Paliu. During the resulting outbreak, a total of 14 symptomatic cases were detected.

Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study

June 1, 2021 - 15:51 -- Open Access
Kho S, Qotrunnada L, Anstey NM, et al.
PLoS Med. 2021 May 26;18(5):e1003632

A very large biomass of intact asexual-stage malaria parasites accumulates in the spleen of asymptomatic human individuals infected with Plasmodium vivax. The mechanisms underlying this intense tropism are not clear. We hypothesised that immature reticulocytes, in which P. vivax develops, may display high densities in the spleen, thereby providing a niche for parasite survival.

Baseline Asymptomatic Malaria Infection and Immunogenicity of rVSVdeltaG-ZEBOV-GP Vaccine: The Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE)

May 25, 2021 - 15:01 -- Open Access
Mahon BE, Simon J, Widdowson MA, Samai M, Rogier E, Legardy-Williams J, Liu K, Schiffer J, Lange J, DeByle C, Pinner R, Schuchat A, Slutsker L, Goldstein S
J Infect Dis. 2021 May 20:jiab243

The effect of malaria infection on rVSVΔG-ZEBOV-GP (ERVEBO®) immunogenicity is unknown.


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