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NOT Open Access | Using pastoralist community knowledge to locate and treat dry-season mosquito breeding habitats with pyriproxyfen to control Anopheles gambiae s.l. and Anopheles funestus s.l. in rural Tanzania

January 12, 2021 - 14:35 -- NOT Open Access
Lupenza ET, Kihonda J, Limwagu AJ, Ngowo HS, Sumaye RD, Lwetoijera DW
Parasitol Res. 2021 Jan 6

Fundamentally, larviciding with pyriproxyfen (PPF) has potential to complement Long Lasting Insecticide Nets (LLINs) and indoor residual sprays (IRS) in settings where resistance to pyrethroids and residual malaria transmission exist. In this study, we evaluated the field effectiveness of larviciding using PPF to reduce dry season productivity of mosquito breeding habitats that were located by pastoralists within the study area.

Efficacy of Royal Guard, a new alpha-cypermethrin and pyriproxyfen treated mosquito net, against pyrethroid-resistant malaria vectors

July 26, 2020 - 13:47 -- Open Access
Ngufor C, Agbevo A, Fagbohoun J, Fongnikin A, Rowland M
Sci Rep. 2020 Jul 22;10(1):12227

Royal Guard is a new insecticide-treated bed-net incorporated with a mixture of alpha-cypermethrin and pyriproxyfen (an insect growth regulator). We assessed its efficacy and wash-resistance in laboratory and experimental hut studies following WHO guidelines. Mosquitoes that survived exposure to the net were kept in separate oviposition chambers and observed for the reproductive effects of pyriproxyfen.

Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial

December 9, 2019 - 15:33 -- Open Access
Kobié H. Toé, Frank Mechan, Julie-Anne A. Tangena, Marion Morris, Joanna Solino, Emile F. S. Tchicaya, Alphonse Traoré, Hanafy Ismail, James Maas, Natalie Lissenden, Margaret Pinder, Steve W. Lindsay, Alfred B. Tiono, Hilary Ranson and N’Falé Sagnon
Malaria Journal 2019 18:383, 2 December 2019

Long-lasting insecticidal nets (LLINs) treated with pyrethroids are the foundation of malaria control in sub-Saharan Africa. Rising pyrethroid resistance in vectors, however, has driven the development of alternative net formulations. Here the durability of polyethylene nets with a novel combination of a pyrethroid, permethrin, and the insect juvenile hormone mimic, pyriproxyfen (PPF), compared to a standard permethrin LLIN, was assessed in rural Burkina Faso.

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