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Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.

November 18, 2009 - 12:28 -- Kabogo Ndegwa
Reinhold Kerb, Richard Fux, Klaus Mörike, Peter G Kremsner, José Pedro Gil, Christoph H Gleiter, Matthias Schwab.
The Lancet Infectious Diseases, Volume 9, Issue 12, December 2009, Pages 760-774, doi:10.1016/S1473-3099(09)70320-2.

The prevention and management of malaria is primarily based on the use of drugs. Clinical trials have however revealed that between individuals there is large variability in the pharmacokinetic profiles of many antimalarial drugs. The resulting variations in concentrations of the drug within plasma might lead to either suboptimum effectiveness or drug toxicity in some patients.

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