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metabolism

Review: Central carbon metabolism of Plasmodium parasites

December 20, 2010 - 10:41 -- Patrick Sampao
Author(s): 
Kellen L. Olszewski, Manuel Llinás
Reference: 
Molecular and Biochemical Parasitology, Volume 175, Issue 2, February 2011, Pages 95-103

We focus primarily on the blood stages of Plasmodium falciparum, the most lethal of the human malaria parasites, but also integrate results from simian, avian and rodent models of malaria that were a major focus of early investigations into plasmodial metabolism.

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Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.

November 18, 2009 - 12:28 -- Kabogo Ndegwa
Author(s): 
Reinhold Kerb, Richard Fux, Klaus Mörike, Peter G Kremsner, José Pedro Gil, Christoph H Gleiter, Matthias Schwab.
Reference: 
The Lancet Infectious Diseases, Volume 9, Issue 12, December 2009, Pages 760-774, doi:10.1016/S1473-3099(09)70320-2.

The prevention and management of malaria is primarily based on the use of drugs. Clinical trials have however revealed that between individuals there is large variability in the pharmacokinetic profiles of many antimalarial drugs. The resulting variations in concentrations of the drug within plasma might lead to either suboptimum effectiveness or drug toxicity in some patients.

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