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protease inhibitors

Mechanisms of action; Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

November 18, 2009 - 12:21 -- Patrick Sampao
Author(s): 
Pedro A. Moura, John B. Dame, and David A. Fidock
Reference: 
Antimicrobial Agents and Chemotherapy, December 2009, p. 4968-4978, Vol. 53, No. 12, doi:10.1128/AAC.00882-09

Hemoglobin (Hb) degradation is essential for the growth of the intraerythrocytic stages of malarial parasites. This process, which occurs inside an acidic digestive vacuole (DV), is thought to involve the action of four aspartic proteases, termed plasmepsins (PMs). These enzymes have received considerable attention as potential antimalarial drug targets.

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