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GCE Special: Plasmodium falciparum infection in “humanised liver” mice

May 27, 2013 - 20:02 -- Bart G.J. Knols
Jordana G. A. Coelho-dos-Reis, Xiangming Li, Eduardo L. V. Silveira, Rajakumar Mandraju, Soundarapandian Velmurugan, Sumana Chakravarty, Hiroshi Suemizu, Mamoru Ito, B. Kim Lee Sim, Stephen Hoffman, Moriya Tsuji
MWJ 2013, 4, 9
Article type: 

This GCE project aimed to establish “humanised liver” mice capable of supporting the full development of the liver stages of human malaria parasites. This could provide an invaluable opportunity to study various aspects of human malaria without the use of human volunteers. This would include investigating the biology of human malaria parasites in vivo and testing the potency of various agents against human malaria infection. Furthermore, “humanised liver” mice would give us the means by which efficient and economical precursor analysis can be done prior to the more expensive human clinical trials.


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