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GCE Special: Production of a transgenic mosquito, as a flying syringe, to deliver protective vaccine via saliva

May 27, 2013 - 19:15 -- Bart G.J. Knols
Hiroyuki Matsuoka
MWJ 2013, 4, 4
Article type: 

In this GCE project it was aimed to put a gene encoding a pathogen protein into a mosquito chromosome, causing it to express the protein in its saliva and inject it into animals orhumans during the blood-feeding process. It was anticipated that the host would develop antibodies to the recombinant protein. If transgenic mosquitoes whose saliva contained a vaccine protein against a disease are released in an area where the disease is prevalent, people that are bitten daily by these mosquitoes would develop antibodies to the vaccine protein, and ultimately the entire community would be ‘vaccinated’ against the disease. In this situation, mosquitoes would play the role of vaccine deliverers.


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