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Scientific Articles

Not Open Access | Ownership and Use of Insecticide-Treated Nets under Ghana's National Malaria Control Program: What are the correlates

October 16, 2021 - 20:17 -- NOT Open Access
Bawuah A, Ampaw S
Bawuah A, Ampaw S Trop Med Int Health. 2021 Oct 12

Ghana’s National Malaria Control Program distributes free insecticide-treated nets (ITNs) as a malaria control measure. Some households with the ITN do not use it, however. This paper explores the socioeconomic and demographic determinants of ITN ownership and use among Ghanaian families.

Malaria vaccine roller coaster

October 16, 2021 - 20:15 -- Open Access
Nkumama IN, Osier FHA
Nat Microbiol. 2021 Oct 11

Malaria vaccine development has been characterised by excitement and disappointment in equal measure. Candidates that have shown promise in pre-clinical animal models and phase 1/2 clinical trials in volunteers who are malaria naive typically do not make the grade when tested in malaria-endemic populations.

Eliminating malaria in southeast Asia requires more attention on adolescent girls

October 16, 2021 - 20:14 -- Open Access
Poku-Awuku A, Banerji J, de Lauwerier VB, Menendez C, Gonzalez R, Pons-Duran C
Lancet Child Adolesc Health. 2021 Oct 8:S2352-4642(21)00307-2

Malaria is one of the leading causes of death among adolescent girls in southeast Asia. Young adolescent girls (aged 10–14 years), for whom malaria is the eighth highest cause of mortality, are most affected.

Linking functional and molecular mechanisms of host resilience to malaria infection

October 16, 2021 - 20:03 -- Open Access
Kamiya T, Davis NM, Greischar MA, Schneider D, Mideo N
Elife. 2021 Oct 12;10:e65846

It remains challenging to understand why some hosts suffer severe illnesses, while others are unscathed by the same infection. We fitted a mathematical model to longitudinal measurements of parasite and red blood cell density in murine hosts from diverse genetic backgrounds to identify aspects of within-host interactions that explain variation in host resilience and survival during acute malaria infection.

Assessing health system factors affecting access and delivery of IPTp-SP and ITN to pregnant women attending ANC clinics in Ghana

October 16, 2021 - 20:02 -- Open Access
De-Gaulle VF, Magnussen P, Kamgno J, Mbacham W, Orish VN, Tagbor H
BMC Health Serv Res. 2021 Oct 6;21(1):1056

Malaria interventions including use of Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment (IPTp-SP) and distribution of Insecticide Treated Nets (ITNs) have been implemented through ante-natal clinic (ANC) services in Ghana. Yet, the high ANC attendance is not commensurate with the uptake of these interventions, with missed opportunities to deliver the interventions. This study sought to assess the health system factors affecting access and delivery of IPTp-SP and ITN as defined by the Ghana Malaria Policy Guideline to eligible pregnant women attending ANC clinic sessions.

NOT Open Access | patiotemporal Dynamic of the RTS,S/AS01 Malaria Vaccine Target Antigens in Senegal

October 16, 2021 - 20:00 -- NOT Open Access
Diallo MA, L'Ollivier C, Diongue K, Badiane AS, Kodio A, Tall ML, Sy M, Seck MC, Sene D, Ndiaye M, Fall FB, Ranque S, Ndiaye D
Am J Trop Med Hyg. 2021 Oct 11:tpmd210369

The RTS,S/AS01 malaria vaccine confers only moderate protection against malaria. Evidence suggests that the effectiveness of the RTS,S/AS01 vaccine depends upon the parasite population genetics, specifically regarding the circumsporozoite protein haplotypes in the population. We investigated Plasmodium falciparum circumsporozoite protein (PfCSP) gene sequences from two endemic sites in 2018 in Senegal.

Pandemic-related delay of falciparum malaria diagnosis in a traveler leading to cerebral malaria

October 16, 2021 - 19:58 -- Open Access
Schubert L, Thurnher MM, Machold K, Tobudic S, Winkler S
J Travel Med. 2021 Oct 5:taab159

We report the case of a 29-year-old male in whom COVID-19 concerns led to a delayed diagnosis of falciparum malaria.

Metabolomic Analysis of Diverse Mice Reveals Hepatic Arginase-1 as Source of Plasma Arginase in Plasmodium chabaudi Infection

October 16, 2021 - 13:13 -- Open Access
Davis NM, Lissner MM, Richards CL, Chevée V, Gupta AS, Gherardini FC, Schneider DS
mBio. 2021 Oct 5:e0242421

Infections disrupt host metabolism, but the factors that dictate the nature and magnitude of metabolic change are incompletely characterized. To determine how host metabolism changes in relation to disease severity in murine malaria, we performed plasma metabolomics on eight Plasmodium chabaudi-infected mouse strains with diverse disease phenotypes. We identified plasma metabolic biomarkers for both the nature and severity of different malarial pathologies. A subset of metabolic changes, including plasma arginine depletion, match the plasma metabolomes of human malaria patients, suggesting new connections between pathology and metabolism in human malaria.

The relationship between markers of antenatal iron stores and birth outcomes differs by malaria prevention regimen-a prospective cohort study

October 16, 2021 - 13:11 -- Open Access
Unger HW, Laurita Longo V, Bleicher A, Ome-Kaius M, Karl S, Simpson JA, Karahalios A, Aitken EH, Rogerson SJ
BMC Med. 2021 Oct 5;19(1):236

Iron deficiency (ID) has been associated with adverse pregnancy outcomes, maternal anaemia, and altered susceptibility to infection. In Papua New Guinea (PNG), monthly treatment with sulphadoxine-pyrimethamine plus azithromycin (SPAZ) prevented low birthweight (LBW; <2500 g) through a combination of anti-malarial and non-malarial effects when compared to a single treatment with SP plus chloroquine (SPCQ) at first antenatal visit. We assessed the relationship between ID and adverse birth outcomes in women receiving SPAZ or SPCQ, and the mediating effects of malaria infection and haemoglobin levels during pregnancy.

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

October 16, 2021 - 13:09 -- Open Access
Larsen MD, Lopez-Perez M, Vidarsson G, et al.
Nat Commun. 2021 Oct 5;12(1):5838

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody responses are a central component of naturally acquired malaria immunity. PfEMP1-specific IgG likely protects by inhibiting IE sequestration and through IgG-Fc Receptor (FcγR) mediated phagocytosis and killing of antibody-opsonized IEs. The affinity of afucosylated IgG to FcγRIIIa is up to 40-fold higher than fucosylated IgG, resulting in enhanced antibody-dependent cellular cytotoxicity.


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