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Scientific Articles

Care-seeking delay of imported malaria to China: Implications for improving post-travel healthcare for migrant workers

October 2, 2021 - 13:08 -- Open Access
Lu G, Cao Y, Chen Q, Zhu G, Müller O, Cao J
J Travel Med. 2021 Sep 28:taab156

Imported malaria cases continue to pose major challenges in China as well as in other countries having achieved elimination. Our study aims to identify the factors influencing the timing of care-seeking after symptom onset among migrant workers with imported malaria, in order to develop innovative interventions to improve access and provision of post-travel healthcare for returning migrants.

NOT Open Access | Seasonal prevalence of Plasmodium falciparum infection and use of insecticide-treated nets among children in three agroecosystems in Aboisso, Cote d'Ivoire

October 2, 2021 - 13:06 -- NOT Open Access
Sadia-Kacou CAM, Adja MA, Assi SB, Poinsignon A, Coulibaly JT, Ouattara AF, Remoué F, Koudou BG, Tano Y
Parasitol Res. 2021 Sep 29

Agroecosystems have been associated with risk of malaria. The aim of this study was to determine the relationship between three agroecosystems: (i) rubber plantation (RP); (ii) oil palm plantation (OPP); (iii) no cash crop plantation (NCCP) and the prevalence of Plasmodium falciparum infection among children living in the Aboisso region. In the three villages within (Ehania-V5) or close (N'zikro) or far from (Ayébo) to each agroecosystem (RP, OPP, and NCCP), two cross-sectional parasitological surveys were carried out during the dry and the peak of the long wet seasons. A total of 586 children aged 1-14 years were recruited in the three villages to determine the prevalence of malaria using conventional microscopy.

NOT Open Access | Impairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variants

October 2, 2021 - 13:00 -- NOT Open Access
Palasuwan D, Palasuwan A, Boonpeng K, Ketprasit N, Imwong M, Kulkeaw K
J Infect Dis. 2021 Sep 24:jiab484

Protection against Plasmodium falciparum is observed in a population deficient in glucose-6-phosphate dehydrogenase (G6PD), particularly in African and Mediterranean regions. However, such protection remains unknown among G6PD-deficient individuals in Southeast Asia. Here, we assessed the invasion and maturation of P. falciparum K1 in a culture of erythrocytes isolated from Thai subjects carrying Viangchan (871G>A) and Mahidol (487G>A).

Not Open Access | Extrinsic parameter's adjustment and potential implications in Plasmodium falciparum malaria diagnosis

October 2, 2021 - 12:59 -- NOT Open Access
Vijayalakshmi A, Rajesh Kanna B, Vijayalakshmi C
Microsc Res Tech. 2021 Sep 23

Malaria is a major public health concern, affecting over 3.2 billion people in 91 countries. The advent of digital microscopy and Machine learning with the aim of automating Plasmodium falciparum diagnosis extensively depends on the extracted image features. The color of the cells, plasma, and stained artifacts influence the topological, geometrical, and statistical parameters being used to extract image features. During microscopic image acquisition, custom adjustments to the condenser and color temperature controls often have an influence on the extracted statistical features.

Evaluation of the Sysmex XN-31 automated analyser for blood donor malaria screening at Malawi Blood Transfusion Services

September 30, 2021 - 12:55 -- Open Access
M'baya B, Mfune T, Samon A, Hwandih T, Münster M
Vox Sang. 2021 Sep 23

Balancing blood supply safety and sufficiency is challenging in malaria-endemic countries where the risk of transfusion-transmitted malaria (TTM) is ever-present. In support of reducing this risk, our study aimed at evaluating the performance of the Sysmex XN-31 analyser in blood donor malaria screening, as compared with current practice in Malawi.

NOT Open Access | Stress in paradise: effects of elevated corticosterone on immunity and avian malaria resilience in a Hawaiian passerine

September 30, 2021 - 11:11 -- NOT Open Access
Names GR, Schultz EM, Krause JS, Hahn TP, Wingfield JC, Heal M, Cornelius JM, Klasing KC, Hunt KE
J Exp Biol. 2021 Sep 23:jeb.242951

Vertebrates confronted with challenging environments often experience an increase in circulating glucocorticoids, which result in morphological, physiological, and behavioral changes that promote survival. However, chronically elevated glucocorticoids can suppress immunity, which may increase susceptibility to disease. Since the introduction of avian malaria to Hawaii a century ago, low elevation populations of Hawaii Amakihi (Chlorodrepanis virens) have undergone strong selection by avian malaria and evolved increased resilience (the ability to recover from infection), while populations at high elevation with few vectors have not undergone selection and remain susceptible.

NOT Open Access | The return of chloroquine-sensitive Plasmodium falciparum parasites in Jazan region, southwestern Saudi Arabia over a decade after the adoption of artemisinin-based combination therapy: analysis of genetic mutations in the pfcrt gene

September 30, 2021 - 11:08 -- NOT Open Access
Madkhali AM, Abdulhaq AA, Atroosh WM, Ghzwani AH, Zain KA, Ghailan KY, Hamali HA, Mobarki AA, Eisa ZM, Lau YL, Al-Mekhlafi HM
Parasitol Res. 2021 Sep 25

This study investigated the polymorphism in the P. falciparum chloroquine resistance transporter (pfcrt) gene 11 years after chloroquine (CQ) cessation in Jazan region, southwestern Saudi Arabia. Two hundred and thirty-five P. falciparum isolates were amplified to detect mutations in the pfcrt gene. The pfcrt 76 T molecular marker for CQ resistance was detected in 66.4% (156/235) of the isolates, while the K76 CQ-sensitive wild type was detected in 33.6%. The pfcrt 74I and pfcrt 75E point mutations were each found to be present in 56.2% of isolates, while only four isolates (1.7%) were found to carry the pfcrt 72S mutation.

Population genetic structure of the malaria vector Anopheles minimus in Thailand based on mitochondrial DNA markers

September 30, 2021 - 11:06 -- Open Access
Bunmee K, Thaenkham U, Saralamba N, Ponlawat A, Zhong D, Cui L, Sattabongkot J, Sriwichai P
Parasit Vectors. 2021 Sep 26;14(1):496

The malaria vector Anopheles minimus has been influenced by external stresses affecting the survival rate and vectorial capacity of the population. Since An. minimus habitats have continuously undergone ecological changes, this study aimed to determine the population genetic structure and the potential gene flow among the An. minimus populations in Thailand.

Not Open access | Modeling of High-Performance SPR Refractive Index Sensor Employing Novel 2D Materials for detection of Malaria Pathogens

September 29, 2021 - 10:24 -- NOT Open Access
Panda A, Pukhrambam PD
IEEE Trans Nanobioscience. 2021 Sep 27;PP

The present work exhibits a novel design of surface plasmon resonance (SPR) biosensor, which comprises CaF2 prism, TiO2, metal (Ag/Au), PtSe2, 2D materials (graphene/ transition metal dichalcogenides (MoS2/WS2)) and sensing medium, for point-of-care detection of various stages of malaria diseases. The transfer matrix method (TMM) is employed to examine the angular reflectivity of the proposed structure after judiciously optimizing the layer thicknesses and layer numbers.

Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites

September 29, 2021 - 10:20 -- Open Access
Niemand J, van Biljon R, van der Watt M, van Heerden A, Reader J, van Wyk R, Orchard L, Chibale K, Llinás M, Birkholtz LM
ACS Infect Dis. 2021 Sep 27

Kinase-focused inhibitors previously revealed compounds with differential activity against different stages of Plasmodium falciparum gametocytes. MMV666810, a 2-aminopyrazine, is more active on late-stage gametocytes, while a pyrazolopyridine, MMV674850, preferentially targets early-stage gametocytes. Here, we probe the biological mechanisms underpinning this differential stage-specific killing using in-depth transcriptome fingerprinting.


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