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Scientific Articles

Plasmodium falciparum clearance time in Malawian children with cerebral malaria: a retrospective cohort study

October 29, 2021 - 14:22 -- Open Access
Alexuse M. Saidi, Geoffrey Guenther, Rima Izem, Xiaojun Chen, Karl Seydel and Douglas Postels
Malaria Journal 2021 20:408, 18 October 2021

Standard treatment for both uncomplicated and severe malaria is artemisinin derivatives. Delayed parasite clearance times preceded the appearance of artemisinin treatment failures in Southeast Asia. Most worldwide malaria cases are in sub-Saharan Africa (SSA), where clinically significant artemisinin resistance or treatment failure has not yet been detected. The recent emergence of a resistance-conferring genetic mutation in the Plasmodium falciparum parasite in Africa warrants continued monitoring throughout the continent.

Cost-effectiveness analysis of integrated community case management delivery models utilizing drug sellers and community health workers for treatment of under-five febrile cases of malaria, pneumonia, diarrhoea in rural Uganda

October 29, 2021 - 14:19 -- Open Access
Patrick Lubogo, John Edward Lukyamuzi, Deo Kyambadde, Alex Aboda Komakech, Freddy Eric Kitutu and Edgar Mugema Mulogo
Malaria Journal 2021 20:407, 18 October 2021

Malaria, pneumonia and diarrhoea continue to be the leading causes of death in children under the age of five years (U5) in Uganda. To combat these febrile illnesses, integrated community case management (iCCM) delivery models utilizing community health workers (CHWs) or drug sellers have been implemented. The purpose of this study is to compare the cost-effectiveness of delivering iCCM interventions via drug sellers versus CHWs in rural Uganda.

Evidence supporting deployment of next generation insecticide treated nets in Burkina Faso: bioassays with either chlorfenapyr or piperonyl butoxide increase mortality of pyrethroid-resistant Anopheles gambiae

October 29, 2021 - 14:17 -- Open Access
Aristide S. Hien, Dieudonné D. Soma, Roch K. Dabiré, et al.
Malaria Journal 2021 20:406, 18 October 2021

Pyrethroid resistance poses a major threat to the efficacy of insecticide-treated nets (ITNs) in Burkina Faso and throughout sub-Saharan Africa, particularly where resistance is present at high intensity. For such areas, there are alternative ITNs available, including the synergist piperonyl butoxide (PBO)-based ITNs and dual active ingredient ITNs such as Interceptor G2 (treated with chlorfenapyr and alpha-cypermethrin). Before deploying alternative ITNs on a large scale it is crucial to characterize the resistance profiles of primary malaria vector species for evidence-based decision making.

Purification of native histidine-rich protein 2 (nHRP2) from Plasmodium falciparum culture supernatant, infected RBCs, and parasite lysate

October 29, 2021 - 14:15 -- Open Access
Balwan Singh, Jessica N. McCaffery, Amy Kong, Yong Ah, Scott Wilson, Sayan Chatterjee, Deepak Tomar, Michael Aidoo, Venkatachalam Udhayakumar and Eric Rogier
Malaria Journal 2021 20:405, 17 October 2021

Despite the widespread use of histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs), purified native HRP2 antigen is not standardly used in research applications or assessment of RDTs used in the field.

Unlocking the human factor to increase effectiveness and sustainability of malaria vector control

October 29, 2021 - 14:12 -- Open Access
April Monroe, Sarah Moore, Bolanle Olapeju, Alice Payne Merritt and Fredros Okumu
Malaria Journal 2021 20:404, 16 October 2021

Progress in the fight against malaria has stalled in recent years, highlighting the importance of new interventions and tailored approaches. A critical factor that must be considered across contexts and interventions is human behaviour.

Entomological survey in two communes with residual malaria transmission in Gia Lai Province in the central highlands of Vietnam

October 29, 2021 - 14:11 -- Open Access
Thai Quang Nguyen, Manh Duc Nguyen, Vinh Xuan Pham, Huan Mah Ro, Michael D. Edstein, Weng K. Chow, Nicholas J. Martin, Jeffrey C. Hertz and Maysa T. Motoki
Malaria Journal 2021 20:403, 16 October 2021

In 2018, the National Malaria Control Programme in Vietnam switched from prioritizing malaria control to elimination. However, with the ongoing elimination programme, there are still areas where residual malaria transmission persists, including the central highlands. This entomological survey was conducted to evaluate Anopheles diversity and host-seeking activity of Anopheles vectors in two communes with very low malaria transmission in Gia Lai Province.

The provider’s checklist to improve pregnant women coverage by intermittent preventive malaria treatment in Mali: a pilot implementation study

October 29, 2021 - 14:09 -- Open Access
Issa Doumbia, Fomba Seydou, Koné Diakalia and Issam Bennis
Malaria Journal 2021 20:402, 16 October 2021

Intermittent preventive treatment of malaria in pregnancy (IPTp) is a comprehensive treatment protocol of anti-malarial drugs administered to pregnant women to prevent malaria, started at the fourth pregnancy month, with at least three doses of sulfadoxine–pyrimethamine (SP), taken as directly observed treatment (DOT) every 30 days at intervals until childbirth, in combination with other preventive measures. This paper introduces feasibility and adoption concepts as implementation research outcomes (IRO), allowing after a defined intervention, to assess the coverage improvement by IPTp for women attending a reference district hospital in Mali. Specifically, the purpose is to evaluate the feasibility of a reminder tool (provider checklist) to enhance pregnant women’s adoption of information about IPTp-SP uptake as immediate and sustained women practices.

Time to scale up molecular surveillance for anti-malarial drug resistance in sub-saharan Africa

October 29, 2021 - 14:02 -- Open Access
Christian Nsanzabana
Malaria Journal 2021 20:401, 13 October 2021

Artemisinin resistance has emerged and spread in the Greater Mekong Sub-region (GMS), followed by artemisinin-based combination therapy failure, due to both artemisinin and partner drug resistance. More worrying, artemisinin resistance has been recently reported and confirmed in Rwanda. Therefore, there is an urgent need to strengthen surveillance systems beyond the GMS to track the emergence or spread of artemisinin and partner drug resistance in other endemic settings. Currently, anti-malarial drug efficacy is monitored primarily through therapeutic efficacy studies (TES).

Prevalence and associated risk factors of asymptomatic malaria and anaemia among school-aged children in Dara Mallo and Uba Debretsehay districts: results from baseline cluster randomized trial

October 27, 2021 - 14:00 -- Open Access
Zerihun Zerdo, Hilde Bastiaens, Sibyl Anthierens, Fekadu Massebo, Matewos Masne, Gelila Biresaw, Misgun Shewangizaw, Abayneh Tunje, Yilma Chisha, Tsegaye Yohannes and Jean-Pierre Van Geertruyden
Malaria Journal 2021 20:400, 13 October 2021

Despite the growing evidence that malaria and anaemia are two interlinked health problems of school-aged children (SAC) in developing countries, there is scarce information about malaria among SAC in Ethiopia. Moreover, anaemia-related studies were more concentrated in easily accessible areas. This study aimed to assess the prevalence of malaria and anaemia and corresponding risk factors among SAC in Dara Mallo and Uba Debretshay districts, in hard to reach areas, so as to inform appropriate integrated interventions for both diseases.

Analysing malaria events from 1840 to 2020: the narrative told through postage stamps

October 27, 2021 - 13:59 -- Open Access
Bernard Brabin
Malaria Journal 2021 20:399,12 October 2021

The role played by postage stamps in the history of malaria control and eradication has largely gone unrecognized. Scientific investigators of malaria, especially Nobel laureates, were commemorated with special issues, but the work of the World Health Organization (WHO), which promoted an ambitious and global philatelic initiative in 1962 to support global eradication, is generally overlooked.


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