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Scientific Articles

Review: Mosquito immune defenses against Plasmodium infection

February 4, 2010 - 15:19 -- Kabogo Ndegwa
Author(s): 
Chris M. Cirimotich, Yuemei Dong, Lindsey S. Garver, Shuzhen Sim, George Dimopoulos
Reference: 
Developmental & Comparative Immunology, Volume 34, Issue 4, April 2010, Pages 387-395

The causative agent of malaria Plasmodium, has to undergo complex developmental transitions and survive attacks from the mosquito's innate immune system to achieve transmission from one host to another through the vector. 

A within-vector mathematical model of Plasmodium Falciparum and implications of incomplete fertilization on optimal gametocyte sex ratio

February 4, 2010 - 14:01 -- Ingeborg van Schayk
Author(s): 
Miranda I. Teboh-Ewungkem, Thomas Yuster
Reference: 
Journal of Theoretical Biology, In Press, Accepted Manuscript, Available online 1 February 2010

A mathematical model that simulates the within-vector dynamics of Plasmodium falciparum in an Anopheles mosquito is developed, based on experimental data.

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Open Access | Review: History of the discovery of the malaria parasites and their vectors

February 4, 2010 - 13:43 -- Ingeborg van Schayk
Author(s): 
Cox FE
Reference: 
Parasites & Vectors 2010, 3:5 (1 February 2010)

This article traces the main events and stresses the importance of comparative studies in that, apart from the initial discovery of parasites in the blood, every subsequent discovery has been based on studies on non-human malaria parasites and related organisms.

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Suggestive Evidence for Darwinian Selection against Asparagine-Linked Glycans of Plasmodium falciparum and Toxoplasma gondii

February 4, 2010 - 13:27 -- Ingeborg van Schayk
Author(s): 
G. Guy Bushkin, Daniel M. Ratner, Jike Cui, Sulagna Banerjee, Manoj T. Duraisingh, Cameron V. Jennings, Jeffrey D. Dvorin, Marc-Jan Gubbels, Seth D. Robertson, Martin Steffen, Barry R. O'Keefe, Phillips W. Robbins, and John Samuelson
Reference: 
Eukaryotic Cell 2010;9 228-241

We are interested in asparagine-linked glycans (N-glycans) of Plasmodium falciparum and Toxoplasma gondii, because their N-glycan structures have been controversial and because we hypothesize that there might be selection against N-glycans in nucleus-encoded proteins that must pass through the endoplasmic reticulum (ER) prior to threading into the apicoplast. 

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Microvesiculation and cell interactions at the brain-endothelial interface In cerebral malaria pathogenesis

February 4, 2010 - 13:18 -- Ingeborg van Schayk
Author(s): 
Valéry Combes, Fatima el-Assaad, Dorothée Faille, Ronan Jambou, Nicholas H Hunt, Georges ER Grau
Reference: 
Progress in Neurobiology, In Press, Accepted Manuscript, Available online 29 January 2010

 No abstract available

Deciphering the Late Biosynthetic Steps of Antimalarial Compound FR-900098

February 4, 2010 - 13:13 -- Ingeborg van Schayk
Author(s): 
Tyler W. Johannes, Matthew A. DeSieno, Benjamin M. Griffin, Paul M. Thomas, Neil L. Kelleher, William W. Metcalf, Huimin Zhao
Reference: 
Chemistry & Biology, Volume 17, Issue 1, 29 January 2010, Pages 57-64

FR-900098 is a potent chemotherapeutic agent for the treatment of malaria. Here we report the heterologous production of this compound in Escherichia coli by reconstructing the entire biosynthetic pathway using a three-plasmid system.

Open Access | Histone Deacetylases Play a Major Role in the Transcriptional Regulation of the Plasmodium falciparum Life Cycle

February 4, 2010 - 11:38 -- Ingeborg van Schayk
Author(s): 
Balbir K. Chaal, Archna P. Gupta, Brigitta D. Wastuwidyaningtyas, Yen-Hoon Luah, Zbynek Bozdech
Reference: 
PLoS Pathog 6(1): e1000737

These findings suggest an important role of histone modification and chromatin remodeling in transcriptional regulation of the Plasmodium life cycle. This also emphasizes the potential of P. falciparum HDACs as drug targets for malaria chemotherapy.

Open Access | Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

February 4, 2010 - 11:25 -- Ingeborg van Schayk
Author(s): 
Kevin N. Couper, Tom Barnes, Julius C. R. Hafalla, Valery Combes, Bernhard Ryffel, Thomas Secher, Georges E. Grau, Eleanor M. Riley, J. Brian de Souza
Reference: 
PLoS Pathog 6(1): e1000744

Here we demonstrate that MPs, derived from the plasma of malaria infected mice, but not naive mice, induce potent activation of macrophages in vitro as measured by CD40 up-regulation and TNF production.

Henoch-Schönlein Purpura Triggered by Falciparum Cerebral Malaria

February 4, 2010 - 11:01 -- Ingeborg van Schayk
Author(s): 
Rajoo Thapa, Debkrishna Mallick, Biswajit Biswas, Apurba Ghosh, Subroto Chakrabartty, and Sandipan Dhar
Reference: 
Clinical Pediatrics. published 28 January 2010

The present report details the case of a young Indian boy with falciparum cerebral malaria, whose clinical course was complicated by the development of a palpable purpuric rash, severe abdominal pain, and grossly bloody stools, leading to the diagnosis of HSP, in accordance with the American College of Rheumatology criteria. 

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Open Access | Exploring the relationship between chronic undernutrition and asymptomatic malaria in Ghanaian children

February 2, 2010 - 21:17 -- Ingeborg van Schayk
Author(s): 
Benjamin T Crookston, Stephen C Alder, Daniel Ansong, et al.
Reference: 
Malaria Journal 2010, 9:39 (2 February 2010)

The conclusion of the study is that children who experienced mild, moderate or severe stunting were not more likely to have asymptomatic malaria than children who were not stunted.

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