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Scientific Articles

Open Access | Clinical Trials and Observations: Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization

January 21, 2010 - 08:00 -- Kabogo Ndegwa
Author(s): 
Julie Makani, Albert N. Komba, Sharon E. Cox, Julie Oruo, Khadija Mwamtemi, Jesse Kitundu, Pius Magesa, Stella Rwezaula, Elineema Meda, Josephine Mgaya, Kisali Pallangyo, Emelda Okiro, David Muturi, Charles R. Newton, Gregory Fegan, Kevin Marsh, and Thomas N. Williams
Reference: 
Blood, 14 January 2010, Vol. 115, No. 2, pp. 215-220.

Approximately 280 000 children are born with sickle cell anemia (SCA) in Africa annually, yet few survive beyond childhood. Falciparum malaria is considered a significant cause of this mortality. 

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Parasitology: Imported malaria in children: incidence and risk factors for severity

January 21, 2010 - 07:52 -- Kabogo Ndegwa
Author(s): 
François Dubosa, Alice Dauriaca, Loubna El Mansoufa, Claude Couroublec, Marie Aurela, Alain Martinota
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 66, Issue 2, February 2010, Pages 169-174

To assess the incidence of imported malaria in children and to determine the frequency of delayed diagnosis and risk factors for severe malaria, we performed a retrospective multicenter cohort study in the northern region of France and included all children with a positive test for malaria from 2000 to 2006.

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Parasitology: Evaluation of rapid diagnostic tests for malaria case management in Gabon

January 21, 2010 - 07:50 -- Kabogo Ndegwa
Author(s): 
Denise Patricia Mawili-Mboumba, Marielle Karine Bouyou Akoteta, Edgard Brice Ngoungoua and Maryvonne Kombila
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 66, Issue 2, February 2010, Pages 162-168

These tests should be considered as a good alternative to microscopy, allowing not only an efficient and rapid diagnosis of malaria in primary health facilities but also to aid in promoting changes for antimalarial prescription behavior.

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Analgesic and antimalarial activities of crude leaf extract and fractions of Acalypha wilkensiana

January 21, 2010 - 07:46 -- Kabogo Ndegwa
Author(s): 
John A. Udobanga, Paul A. Nwafora and Jude E. Okokon
Reference: 
Journal of Ethnopharmacology Volume 127, Issue 2, 3 February 2010, Pages 373-378

Antiplasmodial and analgesic activities of leaf extract and fractions of Acalypha wilkensiana were evaluated to ascertain the folkloric claim of its antimalarial and analgesic activities.

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A bicomponent Plasmodium falciparum investigational vaccine composed of protein-peptide conjugates

January 20, 2010 - 09:42 -- Ingeborg van Schayk
Author(s): 
Joanna Kubler-Kielb, Fathy Majadly, Zuzana Biesova, Christopher P. Mocca, Chunyan Guo, Ruth Nussenzweig, Victor Nussenzweig, Satish Mishra, Yimin Wu, Louis H. Miller, Jerry M. Keith, Teh-Yung Liu, John B. Robbins, and Rachel Schneerson
Reference: 
PNAS January 19, 2010 vol. 107 no. 3 1172-1177

To provide a CSP-based candidate vaccine, we investigated recombinant CSP and NANP conjugates of various peptide lengths, with different N-terminal amino acids, bound at different ratios to various carrier proteins.

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Open Access | Factors affecting fungus-induced larval mortality in Anopheles gambiae and Anopheles stephensi

January 20, 2010 - 09:29 -- Ingeborg van Schayk
Author(s): 
Tullu Bukhari, Anthonieke Middelman, Constantianus JM Koenraadt, Willem Takken, Bart GJ Knols
Reference: 
Malaria Journal 2010, 9:22 (19 January 2010)

Further data on an interesting new approach for biological mosquito larval control.

Open Access | The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis

January 19, 2010 - 19:56 -- Ingeborg van Schayk
Author(s): 
Freya J. I. Fowkes, Jack S. Richards, Julie A. Simpson, James G. Beeson
Reference: 
PLoS Med 7(1): e1000218

A systematic review and meta-analysis examining the association between anti-merozoite antibody responses and incidence of Plasmodium falciparum malaria by Freya Fowkes and colleagues aids identification of antigens that confer protection from malaria.

Open Access | Policy forum: The Global Health System: Linking Knowledge with Action—Learning from Malaria

January 19, 2010 - 19:51 -- Ingeborg van Schayk
Author(s): 
Gerald T. Keusch, Wen L. Kilama, Suerie Moon, Nicole A. Szlezák, Catherine M. Michaud
Reference: 
PLoS Med 7(1): e1000179

In the third in a series of articles on the changing nature of global health institutions, Gerald Keusch and colleagues examine institutional arrangements for malaria research

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Open access | Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum

January 19, 2010 - 19:40 -- Ingeborg van Schayk
Author(s): 
Brehelin L, Florent I, Gascuel O, Marechal E
Reference: 
BMC Genomics 2010, 11:35 (15 January 2010)

We propose a new method that uses gene expression data to assess inter-species annotation transfers.

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