A better understanding of the factors impacting transmission in the highlands is crucial to improve well targeted malaria control strategies.
The PLoS Medicine Editors discuss shortages of artemisinin-based combination therapy in Africa at the point of care and how these can be addressed.
Using a rapid malaria appraisal method, the objective of the study was to provide baseline data about malaria and malaria control in Amazonas State. The authors conclude that malaria control is possible, even in tropical rain forest areas, if the health system is working adequately.
The aim of the study was to better define SNPs in the 5q31 genomic region that could be associated with severe malaria.
Halofantrine (HF) was considered an effective and safe treatment for multi-drug resistant falciparum malaria until 1993, when the first case of drug-associated death was reported.
An outbreak of malaria in Naxalbari, West Bengal, India, in 2005 was investigated to understand determinants and propose control measures.
In combination with spatial data on malaria endemicity and transmission models, movement patterns derived from phone records can inform on the likely sources and rates of malaria importation.
The results suggest that IL4-590C or T alleles participated differently in the regulation of anti-malarial antibody isotype profiles in primary and secondary malaria infection and, therefore, could play an important role in alteration of malaria severity.
The major limit of the microarray technology for this purpose was lack of robustness and with a large number of missing data or with incorrect specificity.