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Scientific Articles

Open Access | A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum

January 6, 2010 - 17:23 -- Ingeborg van Schayk
Bhatt TK, Kapil C, Khan S, Jairajpuri MA, Sharma V, Santoni D, Silvestrini F, Pizzi E, Sharma A
BMC Genomics 2009, 10:644 (31 December 2009)

The completion of Plasmodium genome sequencing and availability of PlasmoDB database has provided a platform for systematic study of parasite genome.

Open Access | Communication: Synthesis and Evaluation of Hybrid Bis-cationic Salts as Antimalarial Drugs

January 6, 2010 - 13:01 -- Patrick Sampao
Stéphanie Ortial, Séverine Denoyelle, Sharon Wein, Olivier Berger, Thierry Durand, Roger Escale, Alain Pellet, Henri Vial, Yen Vo-Hoang
ChemMedChem : Volume 5, Issue 1, Date: January 4, 2010, Pages: 52-55

Resistance is futile: A new series of hybrid bis-cations has been synthesized as potent antimalarial agents.

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Open Access | Ecology: Identification and characterization of odorant-binding protein 1 gene from the Asian malaria mosquito, Anopheles stephensi

January 6, 2010 - 12:56 -- Patrick Sampao
M. S. Sengul, Z. Tu
Insect Molecular Biology : Volume 19, Issue 1, Date: February 2010, Pages: 49-60

Here we report the identification and molecular characterization of the Anopheles stephensi odorant-binding protein 1 gene (AsteObp1), an Obp1 gene in An. stephensi, a major malaria vector in Asia.

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Cell and Molecular Biology: Trafficking of the Phosphoprotein PfCRT to the Digestive Vacuolar Membrane in Plasmodium falciparum

January 6, 2010 - 12:50 -- Patrick Sampao
Yvonne Kuhn, Cecilia P. Sanchez, Daniel Ayoub, Theodora Saridaki, Alain van Dorsselaer, Michael Lanzer
Traffic : Volume 11, Issue 2, Date: February 2010, Pages: 236-249

The digestive vacuole plays an important role in the pathophysiology of the human malaria parasite Plasmodium falciparum.

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Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth

January 6, 2010 - 12:42 -- Patrick Sampao
John R. Gallagher, Sean T. Prigge
Proteins: Structure, Function, and Bioinformatics, Volume 78, Issue 3, Date: 15 February 2010, Pages: 575-588

Together, these results suggest that the apicoplast is a reducing compartment, as suggested by models of P. falciparum metabolism, and that PfACP is maintained in a reduced state during blood stage growth.

Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host

January 6, 2010 - 12:36 -- Patrick Sampao
Dingding Shao, Xiang Zhong, Yan-Feng Zhou, Zhifu Han, Yahui Lin, Zhensheng Wang, Lingyi Bu, Lianhui Zhang, Xiao-Dong Su, Heng Wang
Molecular Immunology, Volume 47, Issue 4, January 2010, Pages 726-737

These data suggest that PyMIF modulates host immune responses together with host MIF and has potential to prolong parasitemia or the chronicity of malaria infection.

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Open Access | Habitat suitability and ecological niche profile of major malaria vectors in Cameroon

January 5, 2010 - 21:00 -- Ingeborg van Schayk
Diego Ayala, Carlo Costantini, Kenji Ose, Guy C Kamdem, Christophe Antonio-Nkondjio, Jean-Pierre Agbor, Parfait Awono-Ambene, Didier Fontenille, Frederic Simard
Malaria Journal 2009, 8:307 (23 December 2009)

The distribution of major malaria vectors in Cameroon is strongly affected by the impact of humans on the environment, with variables related to proximity to human settings being among the best predictors of habitat suitability.

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Open Access | Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria

January 5, 2010 - 20:55 -- Ingeborg van Schayk
Hayder A Giha, Amre Nasr, Nnaemeka C Iriemenam, David Arnot, Marita Troye-Blomberg, Thor G Theander, Klavs Berzins, Gehad ElGhazali, Janardan P Pandey
Malaria Journal 2009, 8:306 (22 December 2009)

The GM allotypes have significant influence on susceptibility to uncomplicated P. falciparum malaria and antigen-dependent influence on total IgG and IgG subclasses.

Open Access | Commentary: Drug procurement, the Global Fund and misguided competition policies

January 5, 2010 - 20:50 -- Ingeborg van Schayk
Richard Tren, Kimberly Hess, Roger Bate
Malaria Journal 2009, 8:305 (22 December 2009)

In an effort to increase competition and decrease price, the Global Fund to Fight AIDS, Tuberculosis and Malaria recently began asking some grant recipients to use international competitive bidding processes for certain drug purchases.


Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria

December 30, 2009 - 08:13 -- Patrick Sampao
Roberta Spaccapelo, Chris J. Janse, Sara Caterbi, Blandine Franke-Fayard{dagger, J. Alfredo Bonilla, Luke M. Syphard, Manlio Di Cristina, Tania Dottorini, Andrea Savarino, Antonio Cassone, Francesco Bistoni, Andrew P. Waters, John B. Dame and Andrea Crisanti
American Journal of Pathology. 2010; 176:205-217

Parasite blood-stage attenuation should help identify protective immune responses against malaria, unravel parasite-derived factors involved in malarial pathologies, such as cerebral malaria, and potentially pave the way for blood-stage whole organism vaccines.


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