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Scientific Articles

Not Open Access | Dihydroartemisinin-piperaquine chemoprevention and malaria incidence after severe flooding: evaluation of a pragmatic intervention in rural Uganda

September 14, 2021 - 09:22 -- NOT Open Access
Author(s): 
Boyce RM, Hollingsworth BD, Mulogo EM, et al.
Reference: 
Clin Infect Dis. 2021 Sep 9:ciab781

Malaria epidemics are a well-described phenomenon after extreme precipitation and flooding, which account for nearly half of global disasters over the past two decades. Yet few studies have examined mitigation measures to prevent post-flood malaria epidemics.

Effectiveness of seasonal malaria chemoprevention (SMC) treatments when SMC is implemented at scale: Case-control studies in 5 countries

September 14, 2021 - 09:19 -- Open Access
Author(s): 
Cairns M, Ceesay SJ, Milligan P, et al.
Reference: 
PLoS Med. 2021 Sep 8;18(9):e1003727

Seasonal malaria chemoprevention (SMC) has shown high protective efficacy against clinical malaria and severe malaria in a series of clinical trials. We evaluated the effectiveness of SMC treatments against clinical malaria when delivered at scale through national malaria control programmes in 2015 and 2016.

A systematic review assessing the potential for release of vector species from competition following insecticide-based population suppression of Anopheles species in Africa

September 14, 2021 - 09:17 -- Open Access
Author(s): 
Qureshi A, Connolly JB
Reference: 
Parasit Vectors. 2021 Sep 8;14(1):462

While insecticide-based vector control can effectively target vector species in areas of high malaria endemicity, such as Anopheles gambiae in Africa, residual disease transmission can occur. Understanding the potential role of competitive displacement between vector species could inform both current insecticide-based vector control programmes and the development of future complementary interventions.

NOT Open Access |Monoclonal antibodies show promise in phase I malaria trial

September 14, 2021 - 09:15 -- NOT Open Access
Author(s): 
Mullard A
Reference: 
Nat Rev Drug Discov. 2021 Sep 6


The US National Institute of Allergy and Infectious Diseases hopes that a monoclonal antibody may provide a means of reducing the impact of malaria.

Improving the quality of malaria diagnosis in southern Africa through the development of a regional malaria slide bank

September 8, 2021 - 17:30 -- Open Access
Author(s): 
Bhavani Moodley, Anderson Chinorumba, Cheryl Hamman, Avhatakali Matamba, Chadwick H. Sikaala, Immo Kleinschmidt and John Frean
Reference: 
Malaria Journal 2021 20:365, 8 September 2021

A malaria slide bank (MSB) is a useful asset for any malaria microscopy testing laboratory to have access to. However, it is not feasible for every country to have its own MSB. If countries are able to pool their resources, a regional MSB is a viable solution. This paper describes the methodology, costing and lessons learnt of establishing and maintaining an MSB over a 3-year period, for a Southern Africa Development Community region.

Urban malaria in sub-Saharan Africa: dynamic of the vectorial system and the entomological inoculation rate

September 8, 2021 - 17:28 -- Open Access
Author(s): 
P. Doumbe-Belisse, E. Kopya, C. S. Ngadjeu, N. Sonhafouo-Chiana, A. Talipouo, L. Djamouko-Djonkam, H. P. Awono-Ambene, C. S. Wondji, F. Njiokou and C. Antonio-Nkondjio
Reference: 
Malaria Journal 2021 20:364, 8 September 2021

Sub-Saharan Africa is registering one of the highest urban population growth across the world. It is estimated that over 75% of the population in this region will be living in urban settings by 2050. However, it is not known how this rapid urbanization will affect vector populations and disease transmission. The present study summarizes findings from studies conducted in urban settings between the 1970s and 2020 to assess the effects of urbanization on the entomological inoculation rate pattern and anopheline species distribution.

New Distribution Records of Anopheles darlingi in Quintana Roo, Southeastern Mexico

September 8, 2021 - 17:23 -- Open Access
Author(s): 
Gómez-Rivera ÁS, Chan-Chablé RJ, Canto-Mis KL, Mis-Ávila PC, Correa-Morales F, Manrique-Saide P
Reference: 
J Am Mosq Control Assoc. 2021 Sep 1;37(3):175-178


Anopheles darlingi is considered the main vector of malaria in the Neotropical region, so knowledge of its distribution in the Americas is highly relevant for the design of strategies for prevention and control of the illness.

Effects of insemination and blood-feeding on locomotor activity of wild-derived females of the malaria mosquito Anopheles coluzzii

September 8, 2021 - 17:21 -- Open Access
Author(s): 
Traoré AS, Porciani A, Moiroux N, Dabiré RK, Simard F, Costantini C, Mouline K
Reference: 
Parasit Vectors. 2021 Sep 7;14(1):457

Behavioural shifts in the canonical location and timing of biting have been reported in natural populations of anopheline malaria vectors following the implementation of insecticide-based indoor vector control interventions. These modifications increase the likelihood of human-vector contact and allow mosquitoes to avoid insecticides, both conditions being favourable to residual transmission of the malarial parasites. The biting behaviour of mosquitoes follows rhythms that are under the control of biological clocks and environmental conditions, modulated by physiological states. In this work we explore modifications of spontaneous locomotor activity expressed by mosquitoes in different physiological states to highlight phenotypic variability associated to circadian control that may contribute to explain residual transmission in the field.

NOT Open Access | A highly invasive malaria parasite has expanded its range to non-migratory birds in North America

September 8, 2021 - 17:19 -- NOT Open Access
Author(s): 
Theodosopoulos AN, Grabenstein KC, Bensch S, Taylor SA
Reference: 
Biol Lett. 2021 Sep;17(9):20210271

Parasite range expansions are a direct consequence of globalization and are an increasing threat to biodiversity. Here, we report a recent range expansion of the SGS1 strain of a highly invasive parasite, Plasmodium relictum, to two non-migratory passerines in North America. Plasmodium relictum is considered one of the world's most invasive parasites and causes the disease avian malaria: this is the first reported case of SGS1 in wild non-migratory birds on the continent.

Are Artemisinin-Based Combination Therapies For Malaria Beginning To Fail in Africa

September 8, 2021 - 17:17 -- Open Access
Author(s): 
Rosenthal PJ
Reference: 
Am J Trop Med Hyg. 2021 Sep 7:tpmd210797

Despite advances in many countries, notably the recent declaration that China is now malaria free, malaria remains entrenched in Africa, where over 90% of malaria morbidity and mortality is seen. 1. In the past, Africa suffered greatly from the effects for resistance to chloroquine, the mainstay of malaria treatment of decades, with increasing mortality from Plasmodium falciparum over the last decades of the 20th century.

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